TABLE 1.
Rate of killing of A. fumigatus conidia by AM from outbred mice in the presence or absence of NADPH oxidase inhibitors and by AM from p47phox−/− mice
| Mouse strain and condition | % Killinga |
|---|---|
| OF1 | |
| Infection in vitro (swollen conidia) | |
| control | 62 ± 5 |
| DPI | 13 ± 5* |
| PAO | 36 ± 4* |
| 129Sv | |
| Infection in vitro (swollen conidia) | |
| p47phox+/+ | 31 ± 1 |
| p47phox−/− | 4 ± 1* |
| Infection in vivo (resting conidia) | |
| p47phox+/+ | 75 ± 6 |
| p47phox−/− | 10 ± 1* |
a
Conditions for killing experiments were a 6-h infection in vitro (ratio of AM to swollen conidia, 10:1) and a 24-h infection in vivo with 105 conidia. *, P < 0.01 for comparison of infected AM with NADPH oxidase inhibitors against infected AM without NADPH inhibitors and for comparison of p47phox−/− against p47phox+/+ mice.