TABLE 2.
Percentages of killing of A. fumigatus conidia by macrophages reported in the literature
| Authors (reference) | Macrophage origina | Method(s)b | Time of infection (h); killing (%) |
|---|---|---|---|
| Roilides et al. (30) | Rabbit | CFU count | 7; 55 |
| Madan et al. (17) | Human | MTT | 1; 50 |
| Robertson et al. (29) | Human | Germination | 3; 25 |
| Schaffner et al. (32) | Rabbit | CFU count | 6; 35 |
| 24; 85 | |||
| Morgenstern et al. (24) | Mouse | CFU count | 6; 86 |
| Levitz et al. (16) | Rabbit | Germination | 6; <10 |
| Michaliszyn et al. (22) | Human | PI | 18; 25 |
| Mouse | 18; 45 | ||
| Meier-Osusky et al. (21) | Human monocytes | CFU count | 18; 50 |
| Roilides et al. (30) | Human MDM | CFU count | 7; 42 |
| Jahn et al. (10) | Human MDM | CFU count, PI | 12; 15 |
| Waldorf et al. (36) | Mouse | Germination | 15; 20 |
| Germination | 18; 70 | ||
| Marr et al. (20) | THP-1 cell line | CFU | 4; 60 |
| FUN-1 | 6; 90 | ||
| Brummer et al. (2) | Mouse | CFU | 2.5; 38 |
a
MDM, monocyte-derived macrophages.
b
MTT, tetrazolium salt colorimetric assay; PI, propidium iodide staining; FUN-1, cell stain (Molecular Probes, Eugene, Org.).