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. Author manuscript; available in PMC: 2006 Aug 28.
Published in final edited form as: J Pharm Pharmacol. 2006 May;58(5):591–598. doi: 10.1211/jpp.58.5.0003

Table 2.

Pharmacokinetic parameters following oral administration of ardeparin in rats

Formulation (route) Cmax(IU mL−1) Tmax(min) AUC0–8h(IU min mL−1) Fabs(%) Frel(%)
Ardeparin alone (oral) 0.13 ± 0.01 232 ± 55 58.5 ± 9.8 2.6 ± 0.4 8.6 ± 1.4
Ardeparin + l-arginine (oral) 0.26 ± 0.01* 90 ± 16* 89.3 ± 7.6* 4.1 ± 0.4* 13.7 ± 1.3*
Ardeparin (i.v.) 0.68 ± 0.02 0 750.3 ± 8.5 100 N/A
Ardeparin (s.c.) 0.61 ± 0.03 120 ± 15 679.9 ± 32.7 90.6 100
*

P < 0.05, compared with ardeparin alone. N/A, not applicable.