Table 1.
Ethnic distribution of the −656 minor T allele in the SERPINH1 gene
| Ethnic group (country) | No. of tested samples | T allele frequency |
|---|---|---|
| Caucasian (Western European) | 148 | 0.041 |
| Bolivian | 92 | 0.046 |
| Mayan (Guatemala) | 40 | 0.075 |
| Mexican | 144 | 0.056 |
| South Asian | 140 | 0.046 |
| Chinese | 43 | 0.083 |
| Nigerian | 76 | 0.11 |
| Creole (Sierra Leone) | 37 | 0.24 |
| Fula (Sierra Leone) | 7 | 0.21 |
| Limba (Sierra Leone) | 23 | 0.24 |
| Loko (Sierra Leone) | 9 | 0.17 |
| Mandigo (Sierra Leone) | 8 | 0.125 |
| Mende (Sierra Leone) | 93 | 0.13 |
| Temne (Sierra Leone) | 59 | 0.25 |
To determine the ancestry of the SERPINH1 alleles, panels of DNA from well characterized populations were genotyped. The analysis indicates that the SERPINH1 −656 T allele is more common in African populations than in South America (Bolivia and Guatemala), Mexico, and Asia (China). Western European populations have a −656 T allele frequency of 0.041.