Table 1.

Comparative structures of hGHRH(1–29)NH₂, GHRH analogs, selective VPAC₁-R antagonist PG 97-269, and VIP

Amino acid residue		1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29
hGHRH (1-29)NH2	H-	Tyr	Ala	Asp	Ala	Ile	Phe	Thr	Asn	Ser	Tyr	Arg	Lys	Val	Leu	Gly	Gln	Leu	Ser	Ala	Arg	Lys	Leu	Leu	Gln	Asp	Ile	Met	Ser	Arg	-NH2
JV-1-36	PhAc-	⋅	D-Arg	⋅	⋅	⋅	Phe(4-CI)	⋅	⋅	Arg	⋅	⋅	⋅	⋅	⋅	Abu	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Nle	D-Arg	Har	-NH2
JV-1-42	PhAc-	His	D-Arg	⋅	⋅	⋅	Phe(4-CI)	⋅	⋅	Arg	⋅	⋅	⋅	⋅	⋅	Abu	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Nle	D-Arg	Har	-NH2
JV-1-50	PhAc-	His	D-Phe	⋅	⋅	⋅	Phe(4-CI)	⋅	⋅	Arg	⋅	⋅	⋅	⋅	⋅	Abu	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Nle	D-Arg	Har	-NH2
JV-1-51	Ac-	His	D-Phe	⋅	⋅	⋅	Phe(4-CI)	⋅	⋅	Arg	⋅	⋅	⋅	⋅	⋅	Abu	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Nle	D-Arg	Har	-NH2
JV-1-38	PhAc-	⋅	D-Arg	⋅	⋅	⋅	Phe(4-CI)	⋅	⋅	Har	Tyr(Me)	⋅	⋅	⋅	⋅	Abu	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Nle	D-Arg	Har	-NH2
JV-1-52	Ac-	His	D-Phe	⋅	⋅	⋅	Phe(4-CI)	⋅	⋅	Har	Tyr(Me)	⋅	⋅	⋅	⋅	Abu	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Nle	D-Arg	Har	-NH2
JV-1-53	Ac-	His	D-Phe	⋅	⋅	⋅	Phe(4-CI)	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Lys	Arg	⋅	⋅	⋅	Lys	⋅	Tyr	⋅	⋅	⋅	⋅	Nle	D-Arg	Har	-NH2
PG 97-269	Ac-	His	D-Phe	⋅	⋅	Val	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Lys	Arg	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	⋅	Leu	-NH2
VIP	H-	His	Ser	⋅	⋅	Val	⋅	⋅	Asp	Asn	⋅	Thr	Arg	Leu	Arg	Lys	⋅	Met	Ala	Val	Lys	⋅	Tyr	⋅	Asn	Ser	⋅	Leu	Asn	-NH2

Amino acid residues identical to those of hGHRH(1-29)NH₂ are denoted by dots.