Table 3.

Inhibitory effects of peptide analogs on the hGHRH(1-29)NH₂-induced GH release in rat pituitary cell superfusion system

Peptide		Inhibition of GH release, %*
Code	Dose	0 min	30 min	60 min	90 min
JV-1-36	10 nM	57	59	61	56
	30 nM†	100	100	100	100
JV-1-38	10 nM	46	53	51	54
	30 nM†	85	98	91	92
JV-1-42	10 nM	62	64	43	34
	30 nM†	97	91	82	76
JV-1-50	30 nM	38	34	25	11
JV-1-51	30 nM	37	0	0	2
JV-1-52	30 nM	72	5	4	4
JV-1-53	30 nM	0	0	0	4
	100 nM	7	4	9	20
PG 97-269	30 nM	5	0	8	17
	100 nM	2	10	9	5

^*Calculated from NET INT of GH responses after the second infusion of 1 nM GHRH (NET INT_GHRH = 1.0) and after simultaneous infusion of 1 nM GHRH and antagonist (NET INT_GHRH+ANT) as 100 × (1.0-NET INT_GHRH+ANT)/1.0. 

^†From ref. 16.