Table 4.
Multi-marker haplotype analyses
| Marker Combination | Global P Value* | Risk Haplotype | Case Count | Case Frequency | Control Count | Control Frequency | Odds Ratio | χ2 | Risk Haplotype P Value |
| Smoking Initiation | |||||||||
| 5-6-7 | 0.0022 | 1-2-1 | 321.9 | 0.363 | 149.6 | 0.307 | 1.3 | 4.34 | 0.0373 |
| 1-2-2 | 11.4 | 0.013 | 0.0 | 0.000 | ∞ | 9.30 | 0.0023 | ||
| 5-6-7-8 | 0.0031 | 1-2-1-2 | 318.2 | 0.358 | 146.6 | 0.301 | 1.3 | 4.74 | 0.0294 |
| 1-2-2-2 | 11.7 | 0.013 | 0.0 | 0.000 | ∞ | 9.66 | 0.0019 | ||
| 1-3-5-6-7 | 0.0035 | 1-1-1-2-1 | 282.2 | 0.318 | 124.7 | 0.256 | 1.6 | 4.22 | 0.0400 |
| 1-1-1-2-2 | 10.16 | 0.011 | 0.0 | 0.000 | ∞ | 8.37 | 0.0038 | ||
| Nicotine Dependence | |||||||||
| 5-6-7 | 0.0514 | 1-2-2 | 9.9 | 0.022 | 1.2 | 0.003 | 8.3 | 6.61 | 0.0102 |
| 5-6-7-8 | 0.0630 | 1-2-2-2 | 10.0 | 0.026 | 1.0 | 0.003 | 8.8 | 7.09 | 0.0077 |
* The empirical p values obtained from 10,000 permutations for combinations 5-6-7, 5-6-7-8 and 1-3-5-6-7 for SI were 0.0090, 0.0114 and 0.0259 respectively.