Figure 2.

Structural equations modeling of the influence of neonatal predictors on the NBAS clusters. (A) The MIMIC model. The details of this model are given in text. Rectangles represent observed variables, circles represent latent variables, one-headed arrows represent influence and double-headed arrows represent covariance. The numbers or identifiers along the arrows are the model parameters. For ease of identification, the one-headed arrows of interest are color coded. Parameters e₁–e₈ represent the errors in measurement of observed variables. (B and C) Standardized regression coefficients for the color coded influences shown in panel A. Numbers indicate the statistical significance. The analysis was first conducted in all neonates (B) and then in neonates with CBL levels below 10 μg/dL (C). (D and E) Standardized indirect effects of the neonatal predictors (x-axis) on the NBAS cluster scores (y-axis). The z-axis represents the magnitude of the effect. Red cylinders indicate a negative effect while green cylinders indicate a positive effect. The analysis was conducted in all neonates (D) and then in neonates with CBL levels below 10 μg/dL (E). Complete results of SEM are shown in Supplementary Table 6 (see additional file 1, supplementary table 6). Abbreviations for the NBAS clusters are: motor (MOT), range of state (RAN), autonomic stability (AUT) and abnormal reflexes (REF).