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. 2006 Jun 23;91(6):2216–2226. doi: 10.1529/biophysj.105.079061

FIGURE 2.

FIGURE 2

The relationship between isometric force and dATP/ATP ratio. Isometric force increases linearly with dATP/ATP ratio at pCa 4.5 (open squares) and nonlinearly at pCa 5.5 (solid diamonds). Active force was normalized to Fmax for ATP (n = 5–7). Lines are the linear least-squares regression (pCa 4.5) or nonlinear least-squares regression fit to Eq. 2 (pCa 5.5). Regression analysis suggests approximately fourfold higher affinity of dATP for cardiac myosin than ATP at pCa 5.5 (Eq. 2). (**p < 0.01 at 10% dATP).