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Comparison of the actomyosin cycle in cardiac contraction for ATP (left) versus dATP (right). The entire actomyosin cross-bridge cycle is shorter with dATP due to an increase in the attachment and detachment rates, as well as overall faster NTP hydrolysis rate during the detached phase (Det). The percentage of the total attached time (Att) during the cycle increases, resulting in a higher isometric duty ratio for dATP than ATP.
