FIGURE 2.

Graph of the dynamic allosteric free energy, ΔΔG, from Eq. 24 (solid) and the enthalpy ΔΔH from Eq. 22 (dashed) and entropy ΔΔS from Eq. 23 (dotted) components of this, against the stiffening of the effective slow-mode spring constant on corepressor binding to the apo-repressor, k′_s/k_s. For two tandem binding repressor dimers, the values plotted are twice those given in Eqs. 22–24. The graph is drawn for, N = 12, , and k_v = 3k_s (see Application to the Met Repressor for a discussion on the choice of these values).