Table 2.

GO analyses of genes assigned to ICA components and to QTC clusters in the AML data set.

	All genes in component		Genes with positive loading		Genes with negative loading
Gene cluster	GO category	ES1	GO category	ES	GO category	ES
C3	extracellular	1.52 × 10-2
	defenes resposne	4.18 × 10-2			defenes resposne	4.70 × 10-3
C6	antigen processing/exogeneous antigen	3.36 × 10-8			antigen processing/exogeneous antigen	2.30 × 10-9
C8	nucleosome assembly	4.39 × 10 -16	nucleosome assembly	1.36 × 10-17
C13	inflammatory respons	1.6 × 10-3			inflammatory respons	5.12 × 10-5
C14			inflammatory respons	4.55 × 10-2
C16	T-cell receptor complex	2.07 × 10-5	T-cell receptor complex	5.4 × 10-6
C17	mitotic cell cycle	2.50 × 10-29	cell communication	2.76 × 10-2	mitotic cell cycle	1.41 × 10-32
C24					defense respons	7.59 × 10-6
C33					defense respons	1.57 × 10-2
C42			extracellular	4.08 × 10-2
C44					respons to wounding	1.68 × 10-2
C45	immune response	6.75 × 10-7			immune response	6.44 × 10-9
C49					Cell-cell adhesion	3.23 × 10-2
C51					defense respons	2.14 × 10-2
C52	cell-cell signalling	2.85 × 10-2
QTC1	immune response	5.5 × 10-9
QTC2	extracellular	9.9 × 10-4
QTC3	intracellullar	1.6 × 10-2
QTC4	mitotic cell cycle	4.3 × 10-28
QTC8	nucleus	9.7 × 10-3
QTC14	unlocalized	3.4 × 10-2
QTC23	organell organization and biogenesis	1.8 × 10-2

¹ES; Step down Bonferroni corrected Ease scores