Table 4.

GO analyses of genes assigned to ICA components and to QTC clusters in the HNSCC data set.

	All genes in component		Genes with positive loading		Genes with negative loading
Gene cluster	GO category	ES1	GO category	ES	GO category	ES
C1	muscle fiber	6.0 10-14	muscle fiber	1.1 10-16
C4	cell communication	3.8 10-3			cell communication	1.0 10-2
C6	immune response	5.7 10-32			defense response	4.1 10-39
C7	xenobiotic metabolism	9.7 10-5	xenobiotic metabolism	9.2 10-5
C8	extracellular	2.8 10-2
C9	extracellular matrix	2.3 10-28	extracellular	2.4 10-2	extracellular matrix	6.5 10-31
C12	extracellular	4.8 10-2
C13	extracellular	1.1 10-2
C15			extracellular	6.0 10-4
C17	membrane	2.5 10-2			membrane	4.3 10-3
C18	extracellular	4.9 10-2	extracellular	4.7 10-3
C20	morphogenesis	1.5 10-2			morphogenesis	1.1 10-2
C26	extracellular	8.9 10-3
C29	extracellular	4.5 10-5	extracellular	2.9 10-5
C30	defense response	5.8 10-17	extracellular	3.4 10-2	defense response	5.8 10-17
C33	ectoderm development	5.7 10-6			ectoderm development	1.74 10-6
C34	response to biotic stimulus	3.6 10-3			response to biotic stimulus	2.83 10-2
C35	extracellular	3.3 10-5	extracellular	1.9 10-3	epidermal differentiation	2.83 10-3
QTC3	defense respons	5 × 10-7
QTC4	ribonucleoprotein complex/ribosome	2.5 × 10-8/5.1 × 10-6
QTC5	extracellular	1.8 × 10-9
QTC8	defense respons/immune respons	1.1 × 10-14/3.9 × 10-14
QTC9	muscle fiber	7.5 × 10-21
QTC10	mitotic cell cycle	9.6 × 10-8
QTC13	mitochondrion	4.7 × 10-8

¹ES; Step down Bonferroni corrected Ease scores