Table 3.
Functional classes of genes induced or repressed by INH (isoniazid) and ETH (ethionamide) treatments.
| INH
|
ETH
|
||||
|---|---|---|---|---|---|
| Functional class | Up | Down | Up | Down | |
| 0 | Virulence, detoxification, adaptation | 0 | 1 | 1 | 1 |
| 1 | Lipid metabolism | 10 | 2 | 15 | 2 |
| 2 | Information pathways | 1 | 4 | 1 | 1 |
| 3 | Cell wall and cell processes | 14 | 2 | 18 | 2 |
| 4 | Stable RNAs | 0 | 0 | 0 | 0 |
| 5 | Insertion seqs and phages | 0 | 1 | 2 | 0 |
| 6 | PE/PPE | 0 | 0 | 0 | 0 |
| 7 | Intermediary metabolism and respiration | 5 | 1 | 7 | 2 |
| 8 | Unknown | 0 | 0 | 0 | 0 |
| 9 | Regulatory proteins | 2 | 0 | 2 | 0 |
| 10 | Conserved hypotheticals | 10 | 10 | 10 | 6 |
| Total | 42 | 21 | 56 | 14 | |
Functional classes are based on TubercuList (http://genolist.pasteur.fr/TubercuList/).