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. 1999 Feb 16;96(4):1732–1737. doi: 10.1073/pnas.96.4.1732

Figure 3.

Figure 3

Liquid absorption in lung explants. (A) Mean whole-lung water content (wet/dry weight ratio) in βENaC m/m mice (closed triangles) and βENaC +/+ mice (open circles). ∗, P < 0.05. (B) Liquid absorptive capacity measured as percentage of cysts that remained inflated after stimulation by 10−5 M cAMP in explants from βENaC m/m (black bars) and +/+ mice (white bars) at E16–E18. (C and D) Short-circuit currents (ΔIsc) in tracheal explants from newborn (C) and adult (D) mice. βENaC +/+ (white bars); βENaC m/m (black bars). Treatment with 10−4 M amiloride (amil), 3 × 10−4 M terbutaline (terb), and 10−4 M UTP, all of which stimulate Cl− secretion, confirms the viability of the βENaC m/m explants.