Physiological measurement in adult βENaC +/+
(white bars) and m/m (dark bars) mice on normal-salt (3 g/kg
Na+) diets. (A) In vivo
measurements of ΔPDamil (βENaC +/+,
n = 16; βENaC m/m, n = 17).
∗∗, P < 0.01. (B) Relative values
of urinary Na+ and K+ normalized with
creatinine (Creat; for each group, n = 17). ∗,
P < 0.05; ∗∗, P < 0.01.
(C) Arterial blood pH and HCO3− (βENaC
+/+, n = 5; βENaC m/m, n
= 7). ∗, P < 0.05. (D)
Plasma aldosterone concentrations (nM; for each group,
n = 7). ∗, P < 0.05.