Table 2.
Apoptosis and proliferation in cell tumour experiments
| Cell line | Control | Treated R115777 | |
| 50 mg/kg | 100 mg/kg | ||
| MCF-7/HER2-18 | |||
| Ki67 (%) | 77.7 (74.4–81.1) | 69.6** (63.4–74.8) | 65.5**** (62.0–70.1) |
| TUNEL (%) | 1.2 (0.9–1.5) | 1.5* (1.2–1.6) | 1.6** (1.4–1.9) |
| CTI | 61.6 (55.5–79.5). | 48.7*** (41.6–57.4) | 38.0**** (30.1–43.3) |
| SKOV3 | |||
| Ki67 (%) | 46.6 (32.0–63.8) | 34.1** (20.3–57.2) | 40.1 (26.6–48.8) |
| TUNEL (%) | 0.35 (0.1–0.8) | 0.49 (0.1–1.0) | 0.48 (0.1–1.4) |
| CTI | 125.4 (87.1–188.9). | 67.5**(45.6–96.1) | 81.0* (38.6–110.2) |
| MDA-MB231 | |||
| Ki67 (%) | 61.7 (54.1–74.6) | 69.3 (56.1–78.0) | 72.4* (43.8–83.1) |
| TUNEL (%) | 0.55 (0.3–0.9) | 0.45 (0.3–0.6) | 0.31* (0.1–0.4) |
| CTI | 106.0 (85.8–191.0). | 180.1 (115.9–205.4) | 180.8 (90.5–227.7) |
Effect of R115777 on proliferation (Ki67), apoptosis (TdT-mediated dUTP-fluorescence nick end labelling [TUNEL]) and cell turnover index (CTI) in cell line tumours grown in athymic nude mice. Values are expressed as median values (interquartile range). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.