Table 4.

Incidence of gastrointestinal adverse events occurring in ≥ 10% of patients during the two year treatment period

	Percentage of patients with event
	Clodronate (n = 530)	Placebo (n = 539)
Nausea	27.0	29.8
Diarrhoea1	19.9	10.0
Dyspepsia	15.6	13.3
Vomiting	14.7	13.1
Abdominal pain	13.6	10.5
Constipation	12.5	12.2
Stomatitis	8.4	10.2

¹P < 0.05 versus placebo.