. 2006 Jun 15;8(3):R28. doi: 10.1186/bcr1503

Table 2.

Hazard ratios for MMP-14, MMP-2, TIMP-2 and combination of MMP-14 MMP-2 TIMP-2 on breast cancer overall survival

	Univariate			Multivariate^a			Multivariate^b
	HR	95% CI	p value	HR	95% CI	p value	HR	95% CI	p value

MMP-14	1.31	0.99–1.72	0.05	1.36	1.03–1.81	0.031	1.18	0.87–1.59	0.28
MMP-2	1.14	0.88–1.47	0.33	1.14	0.87–1.49	0.34	0.98	0.73–1.31	0.87
TIMP-2: stromal cells	0.91	0.69–1.19	0.51	1.04	0.78–1.38	0.79	0.89	0.66–1.19	0.43
TIMP-2: cancer cells	1.07	0.83–1.39	0.61	1.09	0.83–1.43	0.53	1.02	0.77–1.34	0.91
MMP-14-/MMP-2-/TIMP-2+^c	1.0			1.0
MMP-14+/MMP-2+/TIMP-2-	1.46	0.89–2.38	0.13	1.29	0.77–2.16	0.33
Other categories	1.11	0.76–1.63	0.59	1.03	0.68–1.55	0.90

^aCox model adjusting for tumor size and number of involved lymph nodes. ^bCox model adjusting for tumor size, number of involved lymph nodes, HER-2/neu and urokinase plasminogen activator. ^cTIMP-2 by stromal cells. CI, confidence interval; HR, hazard ratio; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteases.