FIG. 3.

Alignment of the deduced primary structure of the C. albicans TOK1 protein with that of S. cerevisiae Tok1p. Both proteins are characterized by eight hydrophobic segments, presumed to be α-helical and membrane spanning, that are designated by boldface type and are labeled S1 to S8. Two pore domains in each protein are designated by bold underlining and are labeled P1 and P2; within the pore domains, the diagnostic K⁺ channel selectivity sequence, GYG, and its congeners (VYG, GLG) are marked by double underlining. Sequence identity between the C. albicans protein and its S. cerevisiae counterpart was found to be 33% overall, 46% in the S1 to S8 spanners, and 71% in the pore domains.