Table 2.
Pt | Age at Dx | Histology of primary | Location of primary | Presenting stage | Failure in IORT field | IORT dose (Gy) | Site of EBRT | Surgical margins | Site of first progression after IORT | Status at last FU | FU (months) |
| |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 86 | Malignant fibrous histiocytoma | Buttock | III | Yes | 12.5 | Buttock | − | Buttock | Dead | 3 |
2 | 68 | Malignant fibrous histiocytoma | Thigh | III | No | 12 | Thigh | − | Acetabulum | AWD | 23 |
| |||||||||||
3 | 18 | Synovial sarcoma | Knee | II | No | 15 | Knee | − | Lungs | AWD | 15 |
4 | 39 | Synovial sarcoma, recurrent | Thigh | IV | No | 15 | Thigh | − | Lungs | AWD | 17 |
5 | 9 | Alveolar rhabdomyosarcoma | Calf | III | No | 12 | None | − | RP LN | AWD | 53 |
6 | 54 | Angiosarcoma | Thigh | II | No | 15 | Thigh | + | Lungs | AWD | 24 |
7 | 9 | Ewing sarcoma | Prox add | IV | No | 12.5 | Prox add | + | Lungs | Dead | 5 |
8 | 18 | Ewing sarcoma | Buttock | IV | No | 12.5 | Buttock | + | Lungs | Dead | 41 |
| |||||||||||
9 | 8 | Monomorphic synovial sarcoma | Forearm | II | No | 12.5 | Forearm | + | None | NED | 39 |
10 | 76 | Malignant fibrous histiocytoma | Groin | III | No | 15 | Groin/add | − | None | NED | 15 |
11 | 59 | Malignant fibrous histiocytoma | Forearm | III | No | 12.5 | Forearm | + | None | NED | 32 |
12 | 31 | Angiomyxoma | Thigh | I | No | 15 | None | − | None | NED | 37 |
13 | 20 | Alveolar rhabdomyosarcoma | Forearm | III | No | 12.5 | Forearm | − | None | NED | 17 |
14 | 21 | Synovial sarcoma | Shoulder | II | No | 12.5 | None | − | None | NED | 11 |
15 | 46 | Synovial sarcoma | Hand | III | No | 12.5 | Hand | + | None | NED | 34 |
16 | 37 | Synovial sarcoma | Popl fossa | II | No | 12.5 | Popl fossa | − | None | NED | 25 |
17 | 38 | Leiomyosarcoma | Groin | II | No | 12.5 | None | − | None | Dead | 23 |
Abbreviations: Pt = patient number; Dx = diagnosis; IORT = intraoperative radiation therapy; EBRT = external beam radiation therapy; FU = follow-up; prox = proximal; add = adductor; popl = popliteal; RP = retroperitoneal; LN = lymph node; AWD = alive with disease; NED = no evidence of disease.
Note: Patients 1–2 failed locoregionally and patients 3–8 failed distantly.