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. 2006 Mar 8;26(10):2684–2691. doi: 10.1523/JNEUROSCI.5257-05.2006

Figure 4.

Figure 4.

Structural evidence that the Kv4.3 subunit-rich specializations are distinct from known chemical synapses. A, A CF terminal in the cerebellar molecular layer establishes an asymmetrical (type I) chemical synapse (arrow) with a PC spine (s) and several membrane specializations (arrowheads) with an IN soma. B–D, High-magnification views of a membrane specialization between a CF terminal and an IN (B), an asymmetrical (type I) chemical synapse made on a Purkinje spine (C), a symmetrical (type II) synaptic junction (D, right), and a punctum adherens (D, left) on an IN dendrite. The presence of presynaptic vesicle clustering distinguishes type I and type II synapses from the CF-IN membrane specializations. Rigid apposition of the presynaptic and postsynaptic membranes characterizes all types of junctions. Scale bars: A, 100 nm; B–D, 50 nm (same magnification).