TABLE 2.

Pharmacokinetic parameters for vancomycin during intermittent administration^a

Compartment	Creatinine clearance (ml/min)	Vamcomycin clearance		V (liters/kg)	kel (h−1)	t1/2β (h)
		ml/min	ml/min/kg
Blood	98 ± 27	113 ± 28	1.55 ± 0.48	0.83 ± 0.29	−0.12 ± 0.03	6.3 ± 1.9
Pleural fluid					−0.11 ± 0.03	6.4 ± 1.5

^aThe values are means ± SDs. V, volume of distribution; k_el, elimination rate constant; t_1/2β, elimination half-life.