TABLE 1.

Summary of comparator-controlled phase III clinical trials of linezolid

Infection and trial description	Treatment regimen	No. of patients	Reference
Nosocomial pneumonia, double-blind, randomized; treatment duration, 7-21 daysa	Linezolid, 600 mg i.v. every 12 h	203	27
	Vancomycin, 1 g i.v. every 12 h	193
Community-acquired pneumonia
Outpatient, investigator-blind, randomized; treatment duration, 10 to 14 days	Linezolid, 600 mg orally every 12 h	274	Cammarata et al. Am. Thoracic Soc., abstr. E73, 2000
	Cefpodoxime, 200 mg orally every 12 h	266
Inpatient, open-label, randomized, treatment duration 7-14 daysa	Linezolid, 600 mg i.v. BIDb and then 600 mg orally every 12 h	381	28
	Ceftriaxone, 1 g i.v. BID and then cefpodoxime 200 mg orally every 12 h	366
Skin and soft tissue infections
Complicated, double-blind, randomized, treatment duration, 10-21 daysa	Linezolid, 600 mg i.v. every 12 h and then 600 mg orally 12 h	400	31
	Oxacillin, 2 g every 6 h and then dicloxacillin 500 mg every 6 h	419
Uncomplicated, double-blind, randomized; treatment duration, 7-14 days	Linezolid, 400 mg orally every 12 h	382	Data on file, Pharmacia Corp., 2000
	Clarithromycin, 250 mg orally every 12 h	371
Uncomplicated, double-blind, randomized; treatment duration, 7-14 days	Linezolid, 400 mg orally every 12 h	166	Duvall et al. Int. Cong. Infect. Dis., abstr. 80.005, 2000
	Clarithromycin, 250 mg orally every 12 h	166
Methicillin-resistant staphylococcal species, open-label, randomized; treatment duration, 7 to 28 daysa	Linezolid, 600 mg i.v. every 12 h and then 600 mg orally every 12 h	240	30
	Vancomycin, 1 g i.v. every 12 h	220

^aThe treatment regimen also included optional aztreonam at 1 to 2 g three times daily.

^bBID, twice a day.