TABLE 2.
Prevention of S. aureus infection using RIP-coated Dacron grafts in the presence or absence of local antibiotic prophylaxis
Antibiotic(s) | Bacterial concn (log CFU/ml [mean ± SD])a
|
|
---|---|---|
MRSA | MSSA | |
Control (untreated) | 7.73 ± 0.11 | 7.49 ± 0.07 |
RIP | 4.52 ± 0.09b,c | 4.64 ± 0.06b,c |
Mupirocin | 2.91 ± 0.16b | 2.84 ± 0.17b |
Mupirocin + RIP | <1b,d,e | <1b,d,e |
Rifampin | 4.85 ± 0.15b | 4.92 ± 0.14b |
Rifampin + RIP | 2.96 ± 0.09b,f | 3.57 ± 0.04b |
Quinupristin-Dalfopristin | 1.68 ± 0.08b | 1.64 ± 0.19b |
Quinupristin-Dalfopristin + RIP | <1b,e | <1b,e |
Levofloxacin | 5.9 ± 0.15b | 4.89 ± 0.14b |
Levofloxacin + RIP | 4.18 ± 0.19b,g | 3.93 ± 0.09b |
n = 15 rats per group.
P < 0.05 versus untreated control group.
P < 0.05 versus mupirocin treatment, and Quinipristin-dalfopristin treatment.
P < 0.05 versus mupirocin treatment.
P < 0.05 versus levofloracin-RIP treatment and rifampin-RIP treatment.
P < 0.05 versus rifampin treatment.
P < 0.05 versus levofloxacin treatment.