TABLE 2.

Inhibition of total viral DNA synthesis at the end of treatment with dual and triple combinations in the postinoculation and preventive protocols^a

Treatment	Low concnb results			High concnc results
	Experimental result	Bliss independence		Experimental result	Bliss independence
		Value	Additivity		Value	Additivity
Postinoculation
DAPD	33 ± 3			62 ± 22
FTC	23 ± 32			81 ± 26
l-FMAU	32 ± 46			67 ± 34
DAPD-l-FMAU	66 ± 2	54 ± 33	SYN	73 ± 38	84 ± 20	>Single
DAPD-FTC	62 ± 30	48 ± 24	SYN	76 ± 18	90 ± 14	>Single
FTC-l-FMAU	70 ± 12	40 ± 57	SYN	82 ± 26	89 ± 15	>Single
DAPD-FTC-l-FMAU	76 ± 2	59 ± 40	SYN	97 ± 5	94 ± 8	SYN
Preinoculation
DAPD	42 ± 33			42 ± 0
FTC	45 ± 3			64 ± 9
l-FMAU	48 ± 13			68 ± 16
DAPD-l-FMAU	60 ± 8	68 ± 24	>Single	78 ± 4	81 ± 9	ADD
DAPD-FTC	58 ± 7	69 ± 16	>Single	83 ± 4	79 ± 5	ADD
FTC-l-FMAU	56 ± 5	71 ± 5	>Single	80 ± 26	87 ± 15	ADD
DAPD-FTC-l-FMAU	67 ± 14	83 ± 12	>Double	91 ± 2	94 ± 2	ADD

^aResults are expressed as percentages of inhibition of viral replication and correspond to the mean values of 3 independent experiments. Abbreviations: ADD, additivity; SYN, synergy; = or >Single, effect equivalent or superior to single drugs.

^bLow concentrations of DAPD, FTC, and l-FMAU are, respectively, 1, 0.5, and 0.1 μM.

^cHigh concentrations of DAPD, FTC, and l-FMAU are, respectively, 2, 1, and 0.5 μM.