TABLE 2.
Treatment | Low concnb results
|
High concnc results
|
||||
---|---|---|---|---|---|---|
Experimental result | Bliss independence
|
Experimental result | Bliss independence
|
|||
Value | Additivity | Value | Additivity | |||
Postinoculation | ||||||
DAPD | 33 ± 3 | 62 ± 22 | ||||
FTC | 23 ± 32 | 81 ± 26 | ||||
l-FMAU | 32 ± 46 | 67 ± 34 | ||||
DAPD-l-FMAU | 66 ± 2 | 54 ± 33 | SYN | 73 ± 38 | 84 ± 20 | >Single |
DAPD-FTC | 62 ± 30 | 48 ± 24 | SYN | 76 ± 18 | 90 ± 14 | >Single |
FTC-l-FMAU | 70 ± 12 | 40 ± 57 | SYN | 82 ± 26 | 89 ± 15 | >Single |
DAPD-FTC-l-FMAU | 76 ± 2 | 59 ± 40 | SYN | 97 ± 5 | 94 ± 8 | SYN |
Preinoculation | ||||||
DAPD | 42 ± 33 | 42 ± 0 | ||||
FTC | 45 ± 3 | 64 ± 9 | ||||
l-FMAU | 48 ± 13 | 68 ± 16 | ||||
DAPD-l-FMAU | 60 ± 8 | 68 ± 24 | >Single | 78 ± 4 | 81 ± 9 | ADD |
DAPD-FTC | 58 ± 7 | 69 ± 16 | >Single | 83 ± 4 | 79 ± 5 | ADD |
FTC-l-FMAU | 56 ± 5 | 71 ± 5 | >Single | 80 ± 26 | 87 ± 15 | ADD |
DAPD-FTC-l-FMAU | 67 ± 14 | 83 ± 12 | >Double | 91 ± 2 | 94 ± 2 | ADD |
Results are expressed as percentages of inhibition of viral replication and correspond to the mean values of 3 independent experiments. Abbreviations: ADD, additivity; SYN, synergy; = or >Single, effect equivalent or superior to single drugs.
Low concentrations of DAPD, FTC, and l-FMAU are, respectively, 1, 0.5, and 0.1 μM.
High concentrations of DAPD, FTC, and l-FMAU are, respectively, 2, 1, and 0.5 μM.