TABLE 4.
Group and duck no. | Viremia (pg/ml)a
|
Viral productionb (AUC) (day 3-31) | Intrahepaticc viral DNA (day 223) | ||
---|---|---|---|---|---|
Day 10 | Day 31 | Day 223 | |||
Controls | |||||
321 | 4.7 | 4.5 | 3.3 | 5.2 | 339 |
322 | 4.3 | 3.4 | 4.9 | ||
323 | 4.2 | 4.2 | 3.1 | 5.0 | 80 |
324 | 4.2 | 4.1 | 3.7 | 4.8 | 1,894 |
325 | 4.2 | 3.1 | 3.5 | 4.9 | 1,693 |
326 | 4.2 | 2.7 | 0.1 | 4.8 | 0.14 |
327 | 3.7 | 1.1 | 4.5 | ||
328 | 4.1 | 3.5 | 3.7 | 4.7 | 345 |
329 | 4.1 | 3.1 | 4.5 | ||
330 | 4.2 | 3.6 | 3.2 | 4.8 | 196 |
Mean | 4.2 ± 0.3 | 3.4 ± 1 | 2.9 ± 1.3 | 4.8 ± 0.2 | 649.5 ± 793.5 |
l-FMAU + FTC | |||||
331 | 2.1 | 0 | 2.7 | ||
332 | 3.7 | 2.9 | 3.2 | 4.3 | 127 |
333 | 1.6 | ||||
334 | 3.6 | 2.9 | 4.7 | ||
335 | 3.5 | 3.4 | 3.4 | 4.4 | 160 |
336 | 2.9 | 0.3 | 3.1 | ||
337 | 3.1 | 1.7 | 0.1 | 4 | 0.86 |
338 | 3.6 | 3.4 | 4.2 | ||
339 | 3.4 | 3.2 | 3.2 | 4 | 425 |
340 | 3.8 | 2.7 | 0.1 | 4.1 | 0.18 |
Mean | 3.1 ± 0.8 | 2.3 ± 1.3 | 2 ± 1.9 | 3.7 ± 0.7 | 142 ± 173.7 |
Viremia was determined after 7 (day 10) and 28 days of treatment (day 31, treatment cessation) and at the end of follow-up (day 223) by real-time PCR as described in Materials and Methods (log10 values are reported).
Estimation of viral production was determined by calculation of the area under the curve (AUC) during the 28 days of treatment (from day 3 to 31) and reported as log10 AUC values.
Quantitation of intrahepatic viral DNA in copies per vge of liver cell DNA by real-time PCR was performed on the remaining ducklings that were sacrificed at the end of the study (day 223).