TABLE 1.
Comparative in vitro activities of dalbavancin against anaerobic gram-positive bacteria and corynebacteria
| Organism (n)a and agent | In vitro activity of dalbavancin (μg/ml)
|
||
|---|---|---|---|
| Range | MIC50 | MIC90 | |
| Actinomyces israelii (11) | |||
| Dalbavancin | 0.06-0.5 | 0.25 | 0.25 |
| Vancomycin | 0.5-1 | 0.5 | 1 |
| Daptomycin | 0.125->32 | 2 | 8 |
| Linezolid | 0.125-16 | 0.5 | 16 |
| Quinupristin-dalfopristin | 0.06-0.25 | 0.125 | 0.25 |
| Imipenem | ≤0.015-0.25 | ≤0.015 | 0.25 |
| Piperacillin-tazobactam | 0.02-4 | 0.02 | 4 |
| Penicillin G | 0.02-0.5 | 0.02 | 0.25 |
| Metronidazole | 0.06->32 | 16 | 32 |
| Clindamycin | 0.02-0.5 | 0.125 | 0.25 |
| Actinomyces spp. (38)b | |||
| Dalbavancin | 0.03-0.5 | 0.025 | 0.5 |
| Vancomycin | 0.25-1 | 0.5 | 1 |
| Daptomycin | 0.02->32 | 4 | 16 |
| Linezolid | 0.25-1 | 0.5 | 1 |
| Quinupristin-dalfopristin | 0.06-0.5 | 0.125 | 0.25 |
| Imipenem | ≤0.015-0.25 | 0.06 | 0.125 |
| Piperacillin-tazobactam | 0.02-2 | 0.5 | 1 |
| Penicillin G | 0.02-0.25 | 0.06 | 0.25 |
| Metronidazole | 0.06->32 | 32 | >32 |
| Clindamycin | 0.02->32 | 0.125 | 0.5 |
| Clostridium clostridioforme (14) | |||
| Dalbavancin | 2-8 | 4 | 8 |
| Vancomycin | 0.25-1 | 0.5 | 1 |
| Daptomycin | 0.25-8 | 2 | 8 |
| Linezolid | 2-8 | 4 | 8 |
| Quinupristin-dalfopristin | 0.5-32 | 0.5 | 8 |
| Imipenem | 0.5-4 | 2 | 2 |
| Piperacillin-tazobactam | 0.125->64 | 1 | 64 |
| Penicillin G | 0.25->32 | 0.5 | >32 |
| Metronidazole | 0.02-0.5 | 0.06 | 0.125 |
| Clindamycin | 0.02-2 | 0.25 | 2 |
| Clostridium difficile (26) | |||
| Dalbavancin | 0.125-0.5 | 0.25 | 0.25 |
| Vancomycin | 0.5-2 | 1 | 2 |
| Daptomycin | 0.25-4 | 1 | 2 |
| Linezolid | 1-16 | 2 | 8 |
| Quinupristin-dalfopristin | 0.25-8 | 0.5 | 4 |
| Imipenem | 2->16 | 4 | 16 |
| Piperacillin-tazobactam | 4-16 | 8 | 16 |
| Penicillin G | 1-4 | 2 | 4 |
| Metronidazole | 0.125-1 | 0.25 | 0.5 |
| Clindamycin | 2->32 | 8 | >32 |
| Clostridium innocuum (15) | |||
| Dalbavancin | 0.125-0.5 | 0.25 | 0.25 |
| Vancomycin | 8-16 | 16 | 16 |
| Daptomycin | 4-8 | 4 | 8 |
| Linezolid | 2-4 | 2 | 4 |
| Quinupristin-dalfopristin | 0.25-2 | 0.5 | 1 |
| Imipenem | 1-2 | 2 | 2 |
| Piperacillin-tazobactam | 0.5-4 | 1 | 2 |
| Penicillin G | 0.25-1 | 0.5 | 0.5 |
| Metronidazole | 0.25-1 | 0.5 | 1 |
| Clindamycin | 0.25-32 | 0.5 | >32 |
| Clostridium perfringens (10) | |||
| Dalbavancin | 0.03-0.125 | 0.06 | 0.125 |
| Vancomycin | 0.5 | 0.5 | 0.5 |
| Daptomycin | 0.5-1 | 1 | 1 |
| Linezolid | 1-2 | 2 | 2 |
| Quinupristin-dalfopristin | 0.25-0.5 | 0.5 | 0.5 |
| Imipenem | 0.06-0.25 | 0.125 | 0.25 |
| Piperacillin-tazobactam | 0.02-0.5 | 0.125 | 0.5 |
| Penicillin G | 0.02-0.125 | 0.06 | 0.125 |
| Metronidazole | 0.5-2 | 1 | 2 |
| Clindamycin | 0.06-1 | 1 | 2 |
| Clostridium ramosum (15) | |||
| Dalbavancin | 0.25-1 | 1 | 1 |
| Vancomycin | 1-4 | 4 | 4 |
| Daptomycin | 8->32 | 32 | >32 |
| Linezolid | 4-8 | 8 | 8 |
| Quinupristin-dalfopristin | 0.25-4 | 0.5 | 4 |
| Imipenem | 0.125-0.5 | 0.25 | 0.5 |
| Piperacillin-tazobactam | 0.06-1 | 0.125 | 0.5 |
| Penicillin G | 0.02-1 | 0.125 | 1 |
| Metronidazole | 0.5-2 | 1 | 2 |
| Clindamycin | 0.125->32 | 2 | >32 |
| Clostridium spp.c (16) | |||
| Dalbavancin | ≤0.015-1 | 0.125 | 0.5 |
| Vancomycin | 0.25->32 | 0.5 | 2 |
| Daptomycin | 0.06-16 | 1 | 8 |
| Linezolid | 0.5-4 | 1 | 4 |
| Quinupristin-dalfopristin | 0.125-0.5 | 0.25 | 0.5 |
| Imipenem | ≤0.015-2 | 0.125 | 1 |
| Piperacillin-tazobactam | 0.02-2 | 0.25 | 2 |
| Penicillin G | 0.02-0.5 | 0.125 | 0.5 |
| Metronidazole | 0.02-2 | 0.5 | 2 |
| Clindamycin | 0.02-8 | 0.06 | 4 |
| Eubacterium spp.d (25) | |||
| Dalbavancin | 0.06-2 | 0.25 | 1 |
| Vancomycin | 0.25-2 | 0.5 | 2 |
| Daptomycin | 0.06->32 | 0.5 | 16 |
| Linezolid | 0.25-8 | 2 | 4 |
| Quinupristin-dalfopristin | 0.02-1 | 2 | 4 |
| Imipenem | ≤0.015-0.5 | 0.03 | 0.5 |
| Piperacillin-tazobactam | 0.02-16 | 0.02 | 16 |
| Penicillin G | 0.02-2 | 0.125 | 2 |
| Metronidazole | 0.02-1 | 0.25 | 1 |
| Clindamycin | 0.02-1 | 0.06 | 0.5 |
| Lactobacillus spp.e (23) | |||
| Dalbavancin | 0.06->32 | 0.5 | >32 |
| Vancomycin | 0.25->32 | 1 | >32 |
| Daptomycin | 0.25->32 | 2 | >32 |
| Linezolid | 0.5-8 | 4 | 8 |
| Quinupristin-dalfopristin | 0.125-2 | 0.5 | 2 |
| Imipenem | ≤0.015-8 | 0.125 | 2 |
| Piperacillin-tazobactam | 0.02-8 | 0.5 | 2 |
| Penicillin G | 0.02-4 | 0.25 | 1 |
| Metronidazole | 0.5->32 | >32 | >32 |
| Clindamycin | 0.02->32 | 0.125 | 2 |
| Propionibacterium spp.f (15) | |||
| Dalbavancin | 0.03-0.5 | 0.25 | 0.5 |
| Vancomycin | 0.5-1 | 0.5 | 1 |
| Daptomycin | 0.5->32 | 1 | 16 |
| Linezolid | 0.25-1 | 0.5 | 1 |
| Quinupristin-dalfopristin | 0.06-0.25 | 0.06 | 0.2 |
| Imipenem | ≤0.015-0.06 | 0.03 | 0.06 |
| Piperacillin-tazobactam | 0.02-1 | 0.02 | 0.5 |
| Penicillin G | 0.02-0.125 | 0.06 | 0.125 |
| Metronidazole | 8->32 | >32 | >32 |
| Clindamycin | 0.02-0.25 | 0.02 | 0.125 |
| Peptostreptococcus spp.g (30) | |||
| Dalbavancin | ≤0.015-0.5 | 0.125 | 0.25 |
| Vancomycin | 0.125-1 | 0.25 | 0.5 |
| Daptomycin | 0.02-32 | 0.25 | 1 |
| Linezolid | 0.5-2 | 0.5 | 2 |
| Quinupristin-dalfopristin | 0.125-0.5 | 0.25 | 0.5 |
| Imipenem | ≤0.015-0.25 | 0.03 | 0.125 |
| Piperacillin-tazobactam | 0.05-8 | 0.05 | 1 |
| Penicillin G | 0.02-4 | 0.125 | 0.25 |
| Metronidazole | 0.125-1 | 0.5 | 1 |
| Clindamycin | 0.02-1 | 0.125 | 0.5 |
| Corynebacterium amycolatum (14) | |||
| Dalbavancin | 0.25-0.5 | 0.25 | 0.5 |
| Vancomycin | 0.25-0.5 | 0.5 | 0.5 |
| Daptomycin | 0.02-0.125 | 0.06 | 0.06 |
| Linezolid | 0.25-0.5 | 0.25 | 0.5 |
| Quinupristin-dalfopristin | 0.125-0.25 | 0.25 | 0.25 |
| Imipenem | 0.03->16 | 0.125 | >16 |
| Piperacillin-tazobactam | 0.02-32 | 8 | 16 |
| Penicillin G | 0.125->32 | 1 | 4 |
| Clindamycin | 0.125->32 | 2 | >32 |
| Corynebacterium jeikeium (12) | |||
| Dalbavancin | 0.5 | 0.5 | 0.5 |
| Vancomycin | 0.5 | 0.5 | 0.5 |
| Daptomycin | 0.125-0.5 | 0.125 | 0.25 |
| Linezolid | 0.25-0.5 | 0.5 | 0.5 |
| Quinupristin-dalfopristin | 0.125-1 | 0.25 | 0.5 |
| Imipenem | 0.06->16 | >16 | >16 |
| Piperacillin-tazobactam | 8->64 | >64 | >64 |
| Penicillin G | 0.5->32 | >32 | >32 |
| Clindamycin | 1->32 | >32 | >32 |
| Corynebacterium spp.h (26) | |||
| Dalbavancin | ≤0.015-1 | 0.25 | 0.5 |
| Vancomycin | 0.25-4 | 0.5 | 1 |
| Daptomycin | 0.02-8 | 0.125 | 8 |
| Linezolid | 0.125-1 | 0.5 | 1 |
| Quinupristin-dalfopristin | 0.06-2 | 0.25 | 1 |
| Imipenem | ≤0.015-4 | 0.03 | 0.25 |
| Piperacillin-tazobactam | 0.02-16 | 0.25 | 16 |
| Penicillin G | 0.02-4 | 0.125 | 1 |
| Clindamycin | 0.02->32 | >32 | >32 |
n = number of isolates tested.
Includes A. gerensceriae (n = 1), A. graevenitzii (n = 1), A. meyeri (n = 3), A. naeslundii (n = 5), A. neuii (n = 1), A. odontolyticus (n = 8), A. radingae (n = 1), A. schalii (n = 1), A. turicensis (n = 7), and A. viscosus (n = 9), as well as Arcanobacterium pyogenes (n = 1).
Includes C. bifermentans (n = 2), C. butyricum (n = 2), C. cadaveris (n = 2), C. cochlearium (n = 2), C. fallax (n = 2), C. glycolicum (n = 2). C. novyi A (n = 1), C. oroticum (n = 1), and C. paraputrificum (n = 2).
Includes E. brachy (n = 1), E. combesii (n = 1), E. contortum (n = 2), E. lentum (n = 5), E. limosum (n = 4), E. saburreum (n = 4), E. tenue (n = 1), E. timidum (n = 4), and E. yurii (n = 3).
Includes L. acidophilus (n = 2), L. brevis (n = 1), L. casei (n = 5), L. catenaforme (n = 3), L. fermentans (n = 2), L. jensenii (n = 1), L. minutus (n = 2), L. oris (n = 1), L. plantarum (n = 5), and L. rhamnosus (n = 1).
Includes P. acnes (n = 5), P. avidum (n = 4), P. granulosum (n = 5), and P. propionicus.
Includes P. anaerobius (n = 7) and P. asaccharolyticus (n = 6), as well as Finegoldia magna (formerly P. magnus) (n = 6), Micromonas micros (formerly P. micros) (n = 6), and P. prevotii (n = 5).
Includes C. accolans (n = 1), “C. aquaticum” (n = 2), C. falsenii (n = 1), C. minutissimum (n = 4), C. pseudodiphtheriticum (n = 4), C. striatum (n = 4), C. urealyticum (n = 1), Corynebacterium CDC group G (n = 1), and Corynebacterium sp. and (no good fit [n = 3]), as well as Dermabacter hominis (n = 4) and Rothia sp. (n = 1).