TABLE 2.
Frequency of katG Ser315 codon mutations among 364 INH-resistant M. tuberculosis isolates determined by PCR-RFLP assay
| Resistance patterna | Case statusb | No. of isolates with mutations/ total no. of isolates tested (%)d |
|---|---|---|
| H | 13/26 (50) | |
| New | 7/17 (41.2) | |
| Treated | 6/9 (66.7) | |
| H, R | 13/23 (56.5) | |
| New | 7/9 (77.8) | |
| Treated | 6/14 (42.6) | |
| H, S | 32/39 (82.1) | |
| New | 27/32 (84.4) | |
| Treated | 5/7 (71.4) | |
| H, E | 1/1 (100) | |
| New | 1/1 (100) | |
| Treated | None | |
| H, R, S | 75/89 (84.3) | |
| New | 29/36 (80.6) | |
| Treated | 46/53 (86.9) | |
| H, R, E | 5/6 (83.3) | |
| New | 4/4 (100) | |
| Treated | 1/2 (50) | |
| H, S, E | 6/8 (75.0) | |
| New | 3/5 (60.0) | |
| Treated | 3/3 (100) | |
| H, R, S, E | 167/172 (97.1) | |
| New | 52/53 (98.1) | |
| Treated | 115/119 (96.6) | |
| H, any | 312/364 (85.7) | |
| New | 130/157 (82.8) | |
| Treated | 182/207 (87.9) | |
| Multiple-drug resistant | 299/338 (88.5) | |
| New | 123/140 (87.9) | |
| Treated | 176/198 (88.9) | |
| MDRc | 260/290 (89.7) | |
| New | 92/102 (90.2) | |
| Treated | 168/188 (89.4) | |
| H, any; R sensitive | 52/74 (70.3) | |
| New | 38/55 (69.1) | |
| Treated | 14/19 (73.7) |
a
Drug resistance abbreviations: H, INH; R, RIF; S, STR; E, EMB. Any, resistant to any other drug.
b
New, isolates recovered from new cases of tuberculosis; treated, isolates recovered from previously treated cases of tuberculosis.
c
Resistant to both INH and RIF at least.
d
For each resistance pattern, the first entry is the total for new and previously treated cases.