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Concentrations of NOR in plasma and EEG effect versus time for the same rat as in Fig. 1. Solid lines represent best PK and PK-PD fits. The parameter values of the PK model are as follows: V = 6240 ml kg−1, k10 = 0.032 min−1, k12 = 0.168 min−1, and k21 = 0.028 min−1. The parameter values of the PK-PD model are as follows: P0 = 0.496 mV2, B = 0.023 mV2 μM−1, n = 7.4, and ke0 = 0.009 min−1.
