TABLE 1.
PK parameter estimates obtained after intravenous infusion of 150 mg of NOR kg−1 in each group of rats by noncompartmental and compartmental approachesa
| Group (n) | Infusion duration (min) | Infusion rate (mg kg−1 min−1) | Approach | Cmaxb (μM) | AUCb (μM • min) | CLb (ml min−1 kg−1) | Vssb (ml kg−1) | t1/2β (min) |
|---|---|---|---|---|---|---|---|---|
| I (8) | 30 | 5 | NC | 188 ± 45 | 29,530 ± 6,495 | 14.9 ± 4.3 | 3,488 ± 757 | 200 ± 31 |
| C | 211 ± 68 | 28,350 ± 6,686 | 15.6 ± 4.6 | 3,444 ± 755 | 175 ± 22 | |||
| II (6) | 120 | 1.25 | NC | 102 ± 15 | 27,860 ± 5,543 | 15.7 ± 3.0 | 3,667 ± 668 | 195 ± 32 |
| C | 104 ± 12 | 27,870 ± 5,458 | 15.8 ± 3.0 | 3,800 ± 779 | 204 ± 37 | |||
| III (8) | 240 | 0.625 | NC | 56 ± 15 | 20,640 ± 4,752 | 21.4 ± 4.7 | 5,075 ± 1,269 | 192 ± 24 |
| C | 57 ± 12 | 21,040 ± 4,698 | 20.7 ± 4.4 | 5,088 ± 1,443 | 210 ± 44 |
a
PK parameter values are means ± standard deviations.
b
Non-statistically significant differences between mean values were determined according to the approach used—compartmental (C) of noncompartmental (NC)—based on the paired Student t test. Statistically significant differences between groups are based on a one-way analysis of variance.