TABLE 2.
PK-PD parameter estimates obtained after an intravenous infusion of 150 mg of NOR kg−1 in rats by the link model approach and the spline function modela
| Group (n) | Infusion rate (mg kg−1 min−1) | Infusion duration (min) | P0 (mV2)b | B (mV2 μM−1)c | nc | ke0 (min−1)b |
|---|---|---|---|---|---|---|
| Group I (8) | 5 | 30 | 0.497 ± 0.222 | 0.017 ± 0.006 | 3.2 ± 2.0 | 0.009 ± 0.003 |
| Group II (6) | 1.25 | 120 | 0.744 ± 0.756 | 0.020 ± 0.005 | 3.0 ± 2.3 | 0.011 ± 0.009 |
| Group III (8) | 0.625 | 240 | 0.401 ± 0.198 | 0.014 ± 0.010 | 1.9 ± 1.3 | 0.029 ± 0.045 |
a
PK-PD parameter values are means ± standard deviations.
b
Non-statistically significant difference between groups were determined based on a nonparametric Kruskall-Wallis test.
c
Non-statistically significant differences between groups were determined based on one-way analysis of variance.