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. 2003 Jun;47(6):1952–1957. doi: 10.1128/AAC.47.6.1952-1957.2003

TABLE 2.

PK-PD parameter estimates obtained after an intravenous infusion of 150 mg of NOR kg−1 in rats by the link model approach and the spline function modela

Group (n) Infusion rate (mg kg−1 min−1) Infusion duration (min) P0 (mV2)b B (mV2 μM−1)c nc ke0 (min−1)b
Group I (8) 5 30 0.497 ± 0.222 0.017 ± 0.006 3.2 ± 2.0 0.009 ± 0.003
Group II (6) 1.25 120 0.744 ± 0.756 0.020 ± 0.005 3.0 ± 2.3 0.011 ± 0.009
Group III (8) 0.625 240 0.401 ± 0.198 0.014 ± 0.010 1.9 ± 1.3 0.029 ± 0.045
a

PK-PD parameter values are means ± standard deviations.

b

Non-statistically significant difference between groups were determined based on a nonparametric Kruskall-Wallis test.

c

Non-statistically significant differences between groups were determined based on one-way analysis of variance.