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. 2003 Jun;47(6):1952–1957. doi: 10.1128/AAC.47.6.1952-1957.2003

TABLE 3.

Comparisons between simulated parameters characteristic of the EEG effect derived from PK-PD effect compartment model modeling conducted in rats from group I and fitted parameters in rats from groups II and IIIa

Group (n) Infusion duration (min) Pmax (mV2)
ΔT (min)
Simulated Fitted Simulated Fitted
I (8) 30 1.642 ± 1.204 112 ± 21
II (6) 120 1.510 ± 1.090b 1.324 ± 0.782b 75 ± 21c 91 ± 96c
III (8) 240 1.260 ± 0.990c 0.589 ± 0.362c 38 ± 16c 39 ± 50c
a

Parameter values are means ± standard deviations.

b

Non-statistically significant differences between simulated and fitted values within group were determined based on the unpaired Student t test.

c

Non-statistically significant differences between simulated and fitted values within group were determined based on the unpaired Student t test with Welch correction.