TABLE 3.
Comparisons between simulated parameters characteristic of the EEG effect derived from PK-PD effect compartment model modeling conducted in rats from group I and fitted parameters in rats from groups II and IIIa
| Group (n) | Infusion duration (min) |
Pmax (mV2)
|
ΔT (min)
|
||
|---|---|---|---|---|---|
| Simulated | Fitted | Simulated | Fitted | ||
| I (8) | 30 | 1.642 ± 1.204 | 112 ± 21 | ||
| II (6) | 120 | 1.510 ± 1.090b | 1.324 ± 0.782b | 75 ± 21c | 91 ± 96c |
| III (8) | 240 | 1.260 ± 0.990c | 0.589 ± 0.362c | 38 ± 16c | 39 ± 50c |
a
Parameter values are means ± standard deviations.
b
Non-statistically significant differences between simulated and fitted values within group were determined based on the unpaired Student t test.
c
Non-statistically significant differences between simulated and fitted values within group were determined based on the unpaired Student t test with Welch correction.