FIG. 2.

Comparative effects of orally administered ACV and BILS 45 BS against HSV-1 dlsptk-induced cutaneous lesions in nude mice. Animals were cutaneously inoculated with 10⁷ PFU per site as described in Materials and Methods. ACV and BILS 45 BS (125 mg/kg/day, three times a day for 10 days) were administered orally as described in the text. (A) Mean lesion scores (12 mice) were significantly (P < 0.05) reduced (after day 3) by BILS 45 BS but not by ACV. (B) AUCs of lesion scores represented as the mean + the SEM of 12 mice per group. The asterisk indicates a P value of <0.05 as determined by ANOVA, followed by Student-Newman-Keuls multiple comparisons.