FIG. 3.

Dose-dependent effects of orally administered BILS 45 BS against HSV-1 dlsptk-induced cutaneous lesions in nude mice. Animals were cutaneously inoculated with 10⁷ PFU per site as described in Materials and Methods. BILS 45 BS (three times per day for 10 days) was administered orally at the doses indicated. (A) Mean lesion scores (12 mice per group). (B) AUCs of lesion scores represented as the mean + the SEM of 12 mice per group. The asterisk indicates a P value of <0.05 as determined by ANOVA, followed by Student-Newman-Keuls multiple comparisons.