FIG. 4.
Comparative effects of orally administered ACV and BILS 45 BS against HSV-1 PAAr5-induced cutaneous lesions in nude mice. Animals were cutaneously inoculated with 107 PFU per site as described in Materials and Methods. ACV and BILS 45 BS (100 mg/kg/day, three times a day for 10 days) were administered orally as described in the text. (A) Mean lesion scores were significantly reduced after day 3 by BILS 45 BS but not by ACV (12 mice per group; P < 0.05). (B) AUCs of lesion scores represented as the mean + the SEM of 12 mice per group. The asterisk indicates a P value of <0.05 as determined by ANOVA, followed by Student-Newman-Keuls multiple comparisons.