TABLE 1.
Antiviral activities of BILS 45 BS and ACV in a plaque reduction assay against wild-type and ACVr strains of HSV-1 in cell culture
| HSV-1 strain | EC50 (μM)a
|
|
|---|---|---|
| BILS 45 BS | ACV | |
| Laboratory isolates | ||
| KOS (WT)b | 0.13 ± 0.02 (8) | 0.97 ± 0.21 (8) |
| dlsptk (ACVr) | 0.14 ± 0.02 (6) | 24.7 ± 2.3 (6) |
| PAAr5 (ACVr) | 0.15 ± 0.03 (6) | 7.8 ± 2.2 (6) |
| Clinical isolates | ||
| 294 (WT) | 0.16 ± 0.02 (6) | 0.68 ± 0.13 (6) |
| 615.8 (ACVr) | 0.25 ± 0.05 (6) | 5.6 ± 1.0 (6) |
| 615.9 (ACVr) | 0.15 ± 0.02 (6) | 29.8 ± 3.6 (6) |
a
Values represent the means ± the SEM from six or eight independent determinations, as indicated by the numbers in parentheses.
b
WT, wild type.