TABLE 1.
Summary of MIC and MIC interpretationa data for isolates of S. pneumoniae from pediatric and adult patients in the United States in 2000-2001 and 2001-2002
| Antimicrobial agent | Patient age (yr) | 2000-2001b
|
2001-2002c
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC (μg/ml)
|
% of isolates that were:
|
MIC (μg/ml)
|
% of isolates that were:
|
||||||||||
| Range | 50% | 90% | S | I | R | Range | 50% | 90% | S | I | R | ||
| Penicillin | <2 | ≤0.03-8 | 0.12 | 2 | 48.5 | 23.1 | 28.3 | ≤0.03->8 | 0.12 | 4 | 45.5 | 20.5 | 34.0 |
| 2-4 | ≤0.03-8 | 0.06 | 2 | 51.0 | 22.2 | 26.8 | ≤0.03->8 | 0.06 | 4 | 53.5 | 17.5 | 28.9 | |
| 5-10 | ≤0.03-4 | ≤0.03 | 2 | 66.3 | 17.6 | 16.1 | ≤0.03-4 | ≤0.03 | 2 | 68.9 | 13.2 | 17.9 | |
| 11-17 | ≤0.03-4 | ≤0.03 | 2 | 65.8 | 14.9 | 19.3 | ≤0.03-8 | ≤0.03 | 2 | 72.0 | 13.4 | 14.7 | |
| 18-64 | ≤0.03->8 | ≤0.03 | 2 | 66.0 | 18.5 | 15.4 | ≤0.03-8 | ≤0.03 | 2 | 69.0 | 15.6 | 15.4 | |
| >64 | ≤0.03-8 | ≤0.03 | 2 | 66.9 | 17.5 | 15.6 | ≤0.03->8 | ≤0.03 | 2 | 69.8 | 14.1 | 16.0 | |
| Amoxicillin-clavulanate | <2 | ≤0.015-8 | 0.06 | 4 | 85.9 | 7.9 | 6.1 | ≤0.015->8 | 0.12 | 4 | 84.2 | 5.9 | 9.9 |
| 2-4 | ≤0.015-8 | 0.06 | 4 | 85.1 | 7.7 | 7.3 | ≤0.015-8 | 0.03 | 4 | 86.4 | 4.9 | 8.8 | |
| 5-10 | ≤0.015-8 | 0.03 | 2 | 93.8 | 4.7 | 1.6 | ≤0.015-8 | 0.03 | 2 | 93.3 | 2.9 | 3.8 | |
| 11-17 | ≤0.015-8 | 0.03 | 2 | 92.1 | 5.3 | 2.6 | ≤0.015-8 | 0.03 | 2 | 91.4 | 4.7 | 3.9 | |
| 18-64 | ≤0.015->8 | 0.03 | 2 | 93.7 | 4.1 | 2.3 | ≤0.015->8 | 0.03 | 2 | 94.4 | 2.2 | 3.4 | |
| >64 | ≤0.015->8 | 0.03 | 2 | 93.9 | 3.8 | 2.3 | ≤0.015->8 | 0.03 | 2 | 94.4 | 2.8 | 2.9 | |
| Ceftriaxone | <2 | ≤0.015-4 | 0.06 | 1 | 94.8 | 2.7 | 2.5 | ≤0.015-8 | 0.12 | 1 | 92.0 | 3.4 | 4.5 |
| 2-4 | ≤0.015-8 | 0.06 | 1 | 91.2 | 3.8 | 5.0 | ≤0.015-4 | 0.06 | 1 | 93.5 | 3.5 | 3.0 | |
| 5-10 | ≤0.015-8 | ≤0.015 | 1 | 96.9 | 1.6 | 1.6 | ≤0.015-8 | 0.03 | 1 | 95.7 | 2.6 | 1.7 | |
| 11-17 | ≤0.015-8 | 0.03 | 1 | 97.4 | 0 | 2.6 | ≤0.015-4 | 0.03 | 1 | 95.3 | 3.9 | 0.9 | |
| 18-64 | ≤0.015-8 | 0.03 | 1 | 97.6 | 1.3 | 1.1 | ≤0.015-8 | 0.03 | 1 | 96.7 | 1.9 | 1.5 | |
| >64 | ≤0.015-8 | 0.03 | 1 | 97.1 | 1.6 | 1.2 | ≤0.015-8 | 0.03 | 1 | 97.5 | 1.5 | 1.0 | |
| Azithromycin | <2 | ≤0.015->32 | 0.06 | >32 | 58.7 | 0.7 | 40.6 | ≤0.015->32 | 0.12 | >32 | 56.0 | 0.5 | 43.5 |
| 2-4 | ≤0.015->32 | 0.06 | >32 | 62.1 | 0 | 37.9 | ≤0.015->32 | 0.12 | >32 | 60.4 | 0 | 39.6 | |
| 5-10 | ≤0.015->32 | 0.06 | 8 | 76.7 | 0 | 23.3 | ≤0.015->32 | 0.06 | >32 | 72.5 | 0 | 27.5 | |
| 11-17 | 0.03->32 | 0.06 | 8 | 74.6 | 0 | 25.4 | 0.03->32 | 0.06 | 8 | 77.2 | 0.4 | 22.4 | |
| 18-64 | ≤0.015->32 | 0.06 | 8 | 74.4 | 0.5 | 25.1 | ≤0.015->32 | 0.06 | 16 | 74.6 | 0.3 | 25.1 | |
| >64 | ≤0.015->32 | 0.06 | 16 | 72.3 | 0.7 | 27.0 | ≤0.015->32 | 0.06 | 16 | 76.2 | 0.2 | 23.6 | |
| SXT | <2 | ≤0.06->4 | 1 | >4 | 47.6 | 8.2 | 44.2 | ≤0.06->4 | 1 | >4 | 48.5 | 6.7 | 44.8 |
| 2-4 | ≤0.06->4 | 0.5 | >4 | 50.2 | 8.8 | 41.0 | ≤0.06->4 | 0.25 | >4 | 56.2 | 6.9 | 36.9 | |
| 5-10 | ≤0.06->4 | 0.25 | >4 | 67.4 | 7.8 | 24.9 | ≤0.06->4 | 0.25 | >4 | 70.1 | 5.7 | 24.2 | |
| 11-17 | ≤0.06->4 | 0.25 | >4 | 66.7 | 7.9 | 25.4 | ≤0.06->4 | 0.25 | >4 | 76.7 | 2.6 | 20.7 | |
| 18-64 | ≤0.06->4 | 0.25 | >4 | 68.8 | 5.1 | 26.1 | ≤0.06->4 | 0.25 | >4 | 71.4 | 5.8 | 22.7 | |
| >64 | ≤0.06->4 | 0.25 | >4 | 67.6 | 6.0 | 26.4 | ≤0.06->4 | 0.25 | >4 | 70.5 | 6.2 | 23.3 | |
| Levofloxacin | <2 | ≤0.06-2 | 0.5 | 1 | 100 | 0 | 0 | 0.25-2 | 0.5 | 1 | 100 | 0 | 0 |
| 2-4 | ≤0.06-1 | 0.5 | 1 | 100 | 0 | 0 | ≤0.06-8 | 0.5 | 1 | 99.8 | 0 | 0.2 | |
| 5-10 | 0.12-1 | 0.5 | 1 | 100 | 0 | 0 | 0.12-8 | 1 | 1 | 99.8 | 0 | 0.2 | |
| 11-17 | 0.5-1 | 1 | 1 | 100 | 0 | 0 | 0.25-2 | 1 | 1 | 100 | 0 | 0 | |
| 18-64 | ≤0.06->8 | 0.5 | 1 | 99.2 | 0.1 | 0.7 | ≤0.06->8 | 1 | 1 | 98.8 | 0.1 | 1.1 | |
| >64 | ≤0.06->8 | 0.5 | 1 | 98.8 | 0.1 | 1.2 | ≤0.06->8 | 1 | 1 | 98.5 | 0.2 | 1.3 | |
Interpreted using NCCLS 2002 breakpoints (19). S, susceptible; I, intermediate; R, resistant.
During 2000-2001, 441 isolates were collected from patients <2 years old, 261 were collected from patients 2 to 4 years old, 193 were collected from patients 5 to 10 years old, 114 were collected from patients 11 to 17 years old, 3,042 were collected from patients 18 to 64 years old, and 2,245 were collected from patients >64 years old.
During 2001-2002, 639 isolates were collected from patients <2 years old, 536 were collected from patients 2 to 4 years old, 418 were collected from patients 5 to 10 years old, 232 were collected from patients 11 to 17 years old, 3,297 were collected from patients 18 to 64 years old, and 2,382 were collected from patients >64 years old.