TABLE 1.

Efficacies of 4-day antibiotic regimens for treatment of experimental endocarditis due to S. aureus

Treatment	Regimen	Mean ± log10 CFU/g of vegetation (no. of sterile vegetations/total no. of vegetations) for strain:
		Lim-1	Lim-2
None (start-of- therapy controls)		9.4 ± 0.9 (0/14)	9.2 ± 1.3 (0/11)
Vancomycin
Standard dose	40 mg/kg every 12 h	7.0 ± 2.3a (1/8)	6.5 ± 2.4a (1/8)
High dose	50 mg/kg every 8 h	6.2 ± 2.0a (2/10)	5.8 ± 2.8a (2/8)
Teicoplanin
Standard dose	20 mg/kg every 12 hb	6.1 ± 2.4a (1/8)	8.3 ± 1.9 (0/14)
High dose	40 mg/kg q 12 hc	Not done	7.0 ± 1.6a (0/9)

^aP < 0.05 versus controls.

^bAfter a loading dose of 40 mg/kg.

^cAfter a loading dose of 80 mg/kg.