Figure 4.

CD4⁺ T cell decline and virus load for the 2-yr period spanning the moment of virus isolation and virus load determination (t = 0). The average CD4⁺ T cell counts per 3-mo interval were calculated for individuals with NSI variants only (○) and individuals with SI variants (●) (a). At the top of a, the number of included patients is shown. The linear regression coefficients (R_c) are depicted. Bars indicate the SEM. For the SI-carrying individuals, the correlation between CD4⁺ T cell decline and the relative virus load (Left) as well as the absolute SI load in the CD45RA⁺ cells (Right) was analyzed (b), and the correlations between the CD45RA⁺ SI load and the decline in CD45RA⁺ (Left) and CD45RO⁺ CD4⁺ T cells (Right) were analyzed (c). The Spearman correlation coefficients (R_s) and the P values are shown.