Table 1. Protein interactions of human RecQ helicases.

APE-1, apurinic/apyrimidinic endonuclease 1; CAF-1, chromatin assembly factor 1; FA, Fanconi's anaemia; SUMO-1, small ubiquitin-related modifier-1; VCP, valosin-containing protein; WHIP, Werner helicase-interacting protein.

RecQ helicase	Physical and/or functional protein interactions
BLM	BRCA1 [208], CAF-1 [270], FA [268], FEN-1 [15,144,146], MLH1 [204,206], p53 [252,255,257], PML [140,271], Rad51 [140,195], RPA [32,92], Top3α [164–167], TRF2 [217,219], WRN [234]
WRN	APE-1 [211], BLM [234], c-Abl [272], DNA-PK [180,181], EXO-1 [149], FEN-1 [58,142,143,145,147,152], Ku70/80 [107,111,112,178,179,273], MRE11 complex [191], p53 [250,251,253–255], PARP-1 [213,214,273], PCNA [274–276], pol β [210], pol δ [125,126], protein kinase A [277], Rad52 [192], RPA [13,32,91,93], SUMO-1 [278], TopI [275,279], TRF2 [60,219,229], VCP [280], WHIP [281]
RECQ4	PML [282], Rad51 [282], UBR1 [283], UBR2 [283]
RECQ5β	RPA [16], Top3α [174], Top3β [174]
RECQ1	EXO-1 [148], MLH1 [148], MSH2/6 [148], Qip1/importin α [284], RPA [43,285], Top3α [165,283]