Figure 3. Biliary cholesterol crystallization and liver histopathology.
Gall-bladder from (A) Gpbar1+/+ mice on chow, (B) Gpbar1+/+ mice on lithogenic diet, (C) Gpbar1−/− mice on chow and (D) Gpbar1−/− mice on lithogenic diet. Polarizing light microscopy of gall-bladder bile from (E) Gpbar1+/+ mice on chow, (F) Gpbar1+/+ mice on lithogenic diet, (G) Gpbar1−/− mice on chow and (H) Gpbar1−/− mice on lithogenic diet. Histological images of liver sections in portal triad from (I) Gpbar1+/+ mice on chow, (J) Gpbar1+/+ mice on lithogenic diet, (K) Gpbar1−/− mice on chow and (L) Gpbar1−/− mice on lithogenic diet. Magnification, ×10 (A–D) and ×400 (E–H). (I–L) Scale bar, 50 μm.