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. 2006 Aug 29;398(Pt 3):393–398. doi: 10.1042/BJ20051933

Figure 5. Calcium binding sites of MMP-12.

Figure 5

The three-dimensional structure for MMP-12 (produced using the coordinates from the PDB-file 1JK3 by the program WebLab ViewerLite 3.20) showing the three calcium ions (green) and their binding sites, numbered from 1–3. The active site is represented by one of the two zinc ions (black), three zinc-co-ordinating histidines, and the inhibitor batimastat. Close up pictures of the calcium binding sites are shown below. Ca402 has six protein contacts while Ca404 and Ca403 have five and four contacts respectively. Site1 is the proposed high-affinity binding site that binds Ca402; site 2 the intermediate-affinity binding site that binds Ca404; site 3 the low-affinity binding site that binds Ca403. Wat, water molecule.