Figure 4. .

Frequency differences between gain and loss CNPs. Of the total set of CNPs that had been corroborated by additional experiments or previously published reports (n=194), the gain (n=66) and loss (n=66) CNPs were divided into bins on the basis of ACNF with a threshold of 10%. A significant reduction in the number of sequence-loss CNPs was observed in the bin of common variants. This bias against common copy-number losses suggests that deletions are subject to purifying selection. Similar observations have been reported for smaller deletion variants (median size ∼7.0 kb).¹⁴