Figure 5. .

Fine structure variation of a common CNP. The CNP initially observed in BAC RP11-142H6 was observed as a common variant found in all subgroups of the HapMap population samples (ACNF 0.46). BAC-based array CGH results (top panel) for eight BAC clones spanning ∼1.5 Mb of chromosome 19 show continuous variability. Fine-tiling oligonucleotide array CGH profiles of the same individuals confirms subtle copy-number differences over the 156-kb interval encompassed by RP11-142H6. Note the close correlation between the log₂ hybridization data from BAC-based array CGH and oligonucleotide microarray data. The recurrent pattern of log₂ ratio data corresponds to a tandem organization of a 60-kb region composed of intrachromosomal segmental duplication (gray bars). Avg. = average.