Table 4. .
Results for Traits That Displayed Genomewide Significance (P<.05) for Either Raw or Ranked Analysis[Note]
| Raw Data |
Ranked Data |
|||||||||
| Covariate | Location | Marker | LOD |
Z (Sum) |
Z (Difference) |
Minimum P | LOD |
Z (Sum) |
Z (Difference) |
Minimum P |
| Anthropometric: | ||||||||||
| BMI | 20q12 | D20S107 | 2.71 | −3.09 | −2.49 | .0202 | 3.04 | −2.88 | −2.81 | .0232 |
| Height | 21q22.3 | D21S266 | … | … | … | … | 3.18 | −1.05 | −3.84 | .0145 |
| Hip circumference | 9q21 | D9S273-D9S175 | 3.09 | −.91 | −3.56 | .0212 | 2.91 | −.83 | −3.50 | .0403 |
| Hip circumference | 20q11-20q13 | D20S195-D20S119 | 3.26 | −2.80 | −3.21 | .0035 | 4.25 | −1.84 | −4.11 | .0015 |
| Waist circumference | 9q21.13 | D9S175 | 2.84 | −2.30 | −2.91 | .0225 | … | … | … | … |
| Weight | 20q11-20q13 | D20S195-D20S178 | 3.70 | −3.33 | −3.23 | .0023 | 3.96 | −2.95 | −3.60 | .0026 |
| Serum chemistry: | ||||||||||
| Albumin/creatinine ratio | 9q33.1 | D9S1776 | … | … | … | … | 3.05 | −3.36 | −2.33 | .0229 |
| Chloride concentration | 9q34.3 | D9S312-D9S1826 | … | … | … | … | 3.43 | −2.37 | −2.90 | .0070 |
| Chloride concentration | 14q11.2 | D14S283 | … | … | … | … | 3.15 | −2.03 | −2.69 | .0315 |
| Total cholesterol | 16p12.3 | D16S3103 | … | … | … | … | 3.10 | −3.59 | −1.23 | .0285 |
| Corrected calcium | 2p22-2p21 | D2S367-D2S2259 | … | … | … | … | 2.85 | −1.12 | −3.53 | .0203 |
| Creatinine | 5p13-5q12 | D5S426-D5S427 | 3.29 | −4.60 | −3.19 | .0015 | 3.51 | −3.77 | −2.41 | .0070 |
| GFR | 5p13-5q12 | D5S426-D5S427 | 3.70 | 3.80 | −1.29 | .0032 | 3.71 | 3.90 | −1.38 | .0050 |
| Sodium | 15q26.2 | D15S657 | … | … | … | … | 2.56 | 3.59 | −.89 | .0350 |
| Tryglyceride | 13q31.3 | D13S265 | 2.65 | −2.57 | −4.67 | .0259 | … | … | … | … |
| Tryglyceride | 13q33.1 | D13S158 | 3.04 | −2.03 | −4.42 | .0473 | … | … | … | … |
| Urea | 5p13-5q11 | D5S426-D5S1969 | 3.29 | −4.24 | −1.68 | .0059 | 3.15 | −3.89 | −.76 | .0149 |
| Blood pressure phenotypic measures: | ||||||||||
| SBP at diagnosis | 15q12 | D15S986 | 2.32 | −3.09 | −.71 | .0454 | … | … | … | … |
| DBP at phenotyping | 3q13.31 | D3S1278 | 2.76 | −1.39 | −3.48 | .0202 | … | … | … | … |
| DBP at phenotyping | 15q23 | D15S131 | 2.94 | 3.73 | .11 | .0136 | … | … | … | … |
| Pulse at phenotyping | 6q27 | D6S264-D6S503 | 3.00 | −1.18 | −3.78 | .0143 | … | … | … | … |
| Pulse at phenotyping | 15q26.2 | D15S130 | … | … | … | … | 2.86 | −2.64 | −3.12 | .0273 |
| Urine chemistry: | ||||||||||
| Albumin/creatinine ratio | 1q43 | D1S2785-D1S2842 | 2.65 | −3.94 | −1.16 | .0260 | … | … | … | … |
| Albumin/creatinine ratio | 9q33.2 | D9S1682 | … | … | … | … | 2.74 | −3.53 | −1.55 | .0298 |
| 24-h Creatinine | 13q22 | D13S156-D13S1812 | 2.49 | 1.58 | −2.40 | .0472 | 2.83 | 2.22 | −2.53 | .0252 |
| Urine creatinine concentration | 13q22 | D13S156-D13S1812 | … | … | … | … | 2.94 | 2.22 | −2.97 | .0255 |
| 24-h Sodium | 4p16.3 | D4S412 | 3.24 | .05 | −3.75 | .0106 | … | … | … | … |
Note.— Z statistics for the sum and difference covariates may be referred to a standard normal distribution.