Table 1.
The effects of RU24858, mometasone and dexamethasone on IL-5 induced human eosinophil survival. Apoptosis was analyzed by morphological criteria. Results are expressed as percentage of apoptotic cells. Values are the mean ± S.E.M., n = 6. * Indicates P < 0.05, ** P < 0.01, *** P < 0.001 as compared with the respective control in the absence of glucocorticoids.
Apoptotic eosinophils (%) | |||
Control | 1 nM IL-5 | 10 nM IL-5 | |
control | 43.3 ± 6.7 | 8.1 ± 1.5 | 9.3 ± 2.5 |
RU24858 1 μM | 51.9 ± 5.5 * | 11.6 ± 3.4 | 10.8 ± 3.8 |
Mometasone 1 μM | 63.1 ± 6.8 *** | 16.0 ± 2.9 ** | 10.8 ± 3.6 |
Dexamethasone 1 μM | 60.1 ± 4.4 ** | 17.1 ± 3.3 ** | 7.7 ± 2.6 |