Table 2.

Estimates of model parameters using non linear mixed models taking into account left-censored (undetectable) values (corrected) or not (crude) with data from ROCO2 clinical trial. N = 17 patients, 100 measures, 12% left-censored.

Parameter	Crude approach		Corrected approach
	Estimate	95% CI	Estimate	95% CI
V0	6.13	5.78; 6.48	6.12	5.77; 6.47
δ	0.13	0.11; 0.17	0.19	0.14; 0.26
c	1.73	1.15; 2.61	1.66	0.88; 3.13
ε	0.89	0.74; 0.96	0.86	0.64; 0.95
${\sigma }_{{\gamma }_0}^2$	0.42	0.082; 0.75	0.41	0.077; 0.74
${\sigma }_{{\gamma }_1}^2$	3.23	0.38; 6.09	3.77	0.38; 7.16
${\sigma }_e^2$	0.071	0.045; 0.097	0.073	0.044; 0.10