Figure 4.

Representative subnetwork diagram describing molecular ancestries in metabolic MANET. A colored scale is use to assign binned ancestry values to enzyme nodes named with EC numbers. The red color represent enzyme nodes with the oldest ancestry (i.e. with ancestry values falling within the oldest range) and the blue color those of youngest ancestry. Some enzymes have more than one structural assignment. They are multidomain proteins or have different structures in different organisms. Colored enzymes with ancestry assignments resulting from HMM-based predictions are distinguished with a "sf" marking at the top right of rectangles depicting enzymatic nodes. Each subnetwork diagram also shows a frequency distribution plot of ancestries.