Fig. 2.

Theoretical response of receptor activity to addition/removal of attractant (Attr) and repellent (Rep) for mixed clusters of adapting (WT) receptors (a) and nonadapting half-methylated or amidated receptors (b) (4Q4E). Attr: 100 μM MeAsp for WT and 50 μM MeAsp at 50 μM ambient MeAsp for 4Q4E. Rep: 100 μM NiCl₂ for WT and 4Q4E. (a Inset) Schematic cluster of receptors with tethered CheR (green) and CheB (red) acting on assistance neighborhoods (within dashed lines). Receptor colors are as follows: high-abundance Tsr (light blue) and Tar (dark blue). (b Inset) Same simulation as a but without employing assistance neighborhoods.